Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477428 | 0.83 | CNR2 (0.64) | CNR2P2RX7ALDH1A1SIGMAR1NR1H2 | |
| SCHEMBL4476194 | 0.81 | CNR2 (0.58) | CNR2P2RX7SIGMAR1CYP2D6 | |
| SCHEMBL4649589 | 0.79 | CNR2 (0.50) | CNR2P2RX7ALDH1A1SIGMAR1CD274 | |
| SCHEMBL27489861 | 0.74 | P2RX7 (0.50) | CNR2P2RX7KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL4468418 | 0.71 | CNR2 (0.64) | CNR2P2RX7KDM4EALDH1A1NR1H2 | |
| SCHEMBL4649711 | 0.71 | CNR2 (0.56) | CNR2P2RX7NR1H2NR1H3LMNA | |
| SCHEMBL4472224 | 0.70 | CNR2 (0.66) | CNR2P2RX7ALDH1A1SIGMAR1BCHE | |
| SCHEMBL16226782 | 0.69 | SIGMAR1 (0.55) | ALDH1A1SIGMAR1NR1H2NR1H3CYP3A4 | |
| SCHEMBL4751823 | 0.68 | CNR2 (0.55) | CNR2P2RX7CYP2D6DRD2DRD4 | |
| SCHEMBL4473536 | 0.68 | CNR2 (0.57) | CNR2ALDH1A1SIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966132-A2 | COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070760-A2 | COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-21 | — | — | WO | disclosed |