Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 14/20 | 0.32 |
| ▸ | BCHE | P06276 | 9/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694755 | 0.90 | OPRK1 (0.32) | SMN1; SMN2 | |
| SCHEMBL4695511 | 0.88 | PDCD1 (0.34) | HDAC1SMN1; SMN2 | |
| SCHEMBL4696628 | 0.88 | HDAC1 (0.35) | HDAC1LTA4HACHEBCHESMN1; SMN2 | |
| SCHEMBL12505524 | 0.87 | ALDH1A1 (0.34) | SMN1; SMN2 | |
| SCHEMBL4693066 | 0.87 | KDM4E (0.34) | HDAC1LTA4HLMNASMN1; SMN2 | |
| SCHEMBL4692560 | 0.87 | CD274 (0.39) | HDAC1LTA4H | |
| SCHEMBL4696335 | 0.87 | PDCD1 (0.44) | LTA4HSMN1; SMN2 | |
| SCHEMBL4691952 | 0.85 | PDCD1 (0.35) | LTA4HLMNA | |
| SCHEMBL4691194 | 0.84 | DRD4 (0.38) | HDAC1LTA4HACHEBCHELMNA | |
| SCHEMBL4695744 | 0.83 | HDAC1 (0.37) | HDAC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | claimed |