Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321127 | 0.84 | KDM4E (0.59) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL11943009 | 0.80 | KDM4E (0.70) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL12778628 | 0.78 | ALDH1A1 (0.47) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL3044752 | 0.76 | KDM4E (0.44) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL1766284 | 0.76 | TSHR (0.45) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL27643814 | 0.76 | KDM4E (0.77) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL12374823 | 0.75 | TERT (0.57) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL3956769 | 0.74 | GRM4 (0.45) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL31197987 | 0.74 | GRM4 (0.45) | KDM4ETDP1TSHRALOX15ACMSD | |
| SCHEMBL13086225 | 0.74 | KDM4E (0.48) | KDM4ETDP1TSHRALOX15ACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |