Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693797 | 0.87 | MAPT (0.51) | POLBTP53LMNATERTMAPT | |
| SCHEMBL4694846 | 0.86 | SMN1; SMN2 (0.40) | POLBMAPTALDH1A1F2KMT2A | |
| SCHEMBL4692884 | 0.86 | LMNA (0.48) | POLBTP53LMNAMAPTALDH1A1 | |
| SCHEMBL4690539 | 0.83 | TP53 (0.45) | TP53LMNAMAPTALDH1A1KMT2A | |
| SCHEMBL4693710 | 0.83 | HCRTR1 (0.52) | POLBTP53LMNAMAPTKMT2A | |
| SCHEMBL4691903 | 0.83 | MEN1 (0.55) | POLBTP53LMNAMAPTALDH1A1 | |
| SCHEMBL4693483 | 0.83 | HCRTR1 (0.48) | TP53LMNAMAPTALDH1A1KMT2A | |
| SCHEMBL4694219 | 0.83 | LMNA (0.46) | POLBTP53LMNAMAPTALDH1A1 | |
| SCHEMBL4694615 | 0.82 | ALDH1A1 (0.46) | POLBTP53LMNAMAPTALDH1A1 | |
| SCHEMBL4694352 | 0.82 | KMT2A (0.47) | POLBTP53LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |