Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751779 | 0.83 | AURKB (0.49) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19748130 | 0.79 | GAA (0.54) | L3MBTL1HTTMAPTKMT2AMEN1 | |
| SCHEMBL5913323 | 0.78 | L3MBTL1 (0.45) | L3MBTL1MAPTKMT2AMEN1GAA | |
| SCHEMBL21580306 | 0.77 | HTT (0.76) | L3MBTL1HTTMAPTKMT2AMEN1 | |
| SCHEMBL15398395 | 0.76 | MAPT (0.53) | HTTSENP1MAPTKMT2AMEN1 | |
| SCHEMBL8220431 | 0.75 | MMP13 (0.55) | HPGDNPC1RAB9A | |
| SCHEMBL30471275 | 0.74 | RIPK1 (0.61) | MAPTKMT2AMEN1GAAHDAC3 | |
| SCHEMBL4765237 | 0.74 | RIPK1 (0.61) | MAPTKMT2AMEN1GAAHDAC3 | |
| SCHEMBL25295609 | 0.74 | NR1H4 (0.58) | KMT2ANPC1MITFMAPK1RAB9A | |
| SCHEMBL2777304 | 0.73 | PDK1 (0.48) | L3MBTL1MAPTKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966163-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | Boehringer Ingelheim International GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007076247-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-07-05 | — | — | WO | disclosed |