Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | FSHR | P23945 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696335 | 0.91 | PDCD1 (0.44) | PDCD1CD274ALDH1A1 | |
| SCHEMBL4692560 | 0.89 | CD274 (0.39) | HDAC1PDCD1CD274 | |
| SCHEMBL4691952 | 0.89 | PDCD1 (0.35) | PDCD1CD274ALDH1A1LMNA | |
| SCHEMBL4695736 | 0.88 | ALDH1A1 (0.40) | HDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL4695511 | 0.88 | PDCD1 (0.34) | HDAC1PDCD1CD274 | |
| SCHEMBL6027383 | 0.87 | OPRM1 (0.36) | HDAC1PDCD1CD274ALDH1A1KMT2A | |
| SCHEMBL4696628 | 0.85 | HDAC1 (0.35) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL12505524 | 0.85 | ALDH1A1 (0.34) | ALDH1A1 | |
| SCHEMBL4695176 | 0.85 | POLB (0.37) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL4694768 | 0.85 | HDAC1 (0.36) | HDAC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | disclosed |