Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 8/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695551 | 0.92 | CNR2 (0.40) | PDCD1CD274SMN1; SMN2LMNAMEN1 | |
| SCHEMBL6027362 | 0.91 | TRPV1 (0.39) | PDCD1CD274ALDH1A1LMNATRPV1 | |
| SCHEMBL4694658 | 0.91 | ALDH1A1 (0.36) | PDCD1CD274ALDH1A1LMNABACE1 | |
| SCHEMBL4696335 | 0.85 | PDCD1 (0.44) | PDCD1CD274ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4691773 | 0.84 | KDM4E (0.41) | PDCD1CD274ALDH1A1LMNAMEN1 | |
| SCHEMBL6027475 | 0.84 | TRPV1 (0.37) | LMNATRPV1 | |
| SCHEMBL4693976 | 0.84 | NPC1 (0.36) | PDCD1CD274ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4695176 | 0.83 | POLB (0.37) | ALDH1A1LMNAKMT2A | |
| SCHEMBL4692631 | 0.83 | ALDH1A1 (0.35) | ALDH1A1LMNAMEN1KMT2ATRPV1 | |
| SCHEMBL4790223 | 0.82 | MCHR1 (0.39) | PDCD1CD274SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | claimed |