Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817716 | 0.87 | SLC6A7 (0.63) | SLC6A7KDM4EALDH1A1L3MBTL1TSHR | |
| SCHEMBL3821678 | 0.85 | ALDH1A1 (0.65) | SLC6A7KDM4EALDH1A1L3MBTL1TSHR | |
| SCHEMBL5935798 | 0.83 | SLC6A7 (0.59) | SLC6A7KDM4EALDH1A1L3MBTL1TSHR | |
| SCHEMBL4699807 | 0.82 | SLC6A7 (0.46) | SLC6A7KDM4EALDH1A1L3MBTL1DRD2 | |
| SCHEMBL3821810 | 0.80 | SLC6A7 (0.44) | SLC6A7KDM4EALDH1A1L3MBTL1TSHR | |
| SCHEMBL3578554 | 0.77 | SLC6A7 (1.00) | SLC6A7ALDH1A1L3MBTL1TSHR | |
| SCHEMBL3578419 | 0.77 | SLC6A7 (0.77) | SLC6A7KDM4EALDH1A1L3MBTL1TSHR | |
| SCHEMBL3817981 | 0.77 | ALDH1A1 (0.64) | SLC6A7KDM4EALDH1A1L3MBTL1TSHR | |
| SCHEMBL3580180 | 0.75 | KDM4E (0.71) | SLC6A7KDM4EALDH1A1L3MBTL1TSHR | |
| SCHEMBL3413095 | 0.74 | P2RX7 (0.62) | KDM4EALDH1A1TSHRSCDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893212-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006124748-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | claimed |
| EP-1893212-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006124748-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | disclosed |