Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 6/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695977 | 0.82 | SLC6A7 (0.62) | SLC6A7DRD2DRD4DRD3KDM4E | |
| SCHEMBL3821810 | 0.77 | SLC6A7 (0.44) | SLC6A7DRD2DRD4DRD3KDM4E | |
| SCHEMBL3584830 | 0.76 | SLC6A7 (0.50) | SLC6A7L3MBTL1CYP2C9USP2CYP1A2 | |
| SCHEMBL3821678 | 0.69 | ALDH1A1 (0.65) | SLC6A7DRD2DRD4DRD3KDM4E | |
| SCHEMBL3817716 | 0.69 | SLC6A7 (0.63) | SLC6A7KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL5935798 | 0.66 | SLC6A7 (0.59) | SLC6A7KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL15416474 | 0.64 | MEN1 (0.58) | KDM4EALDH1A1CYP2C9USP2MAPK1 | |
| SCHEMBL3815687 | 0.64 | MALT1 (0.48) | SLC6A7KDM4EL3MBTL1CYP2C19MEN1 | |
| SCHEMBL3578554 | 0.63 | SLC6A7 (1.00) | SLC6A7ALDH1A1L3MBTL1 | |
| SCHEMBL3580180 | 0.62 | KDM4E (0.71) | SLC6A7KDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893212-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006124748-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | claimed |
| WO-2006124897-A2 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITION | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | disclosed |