Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.90 |
| ▸ | GLA | P06280 | 1/20 | 0.90 |
| ▸ | MAPT | P10636 | 1/20 | 0.90 |
| ▸ | HPGD | P15428 | 1/20 | 0.90 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.90 |
| ▸ | CASP1 | P29466 | 1/20 | 0.90 |
| ▸ | CASP7 | P55210 | 1/20 | 0.90 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.90 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TTR | P02766 | 2/20 | 0.55 |
| ▸ | MGAM | O43451 | 1/20 | 0.55 |
| ▸ | SI | P14410 | 1/20 | 0.55 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xanthone SCHEMBL41161 | 0.94 | MAOA (1.00) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL29398266 | 0.94 | MAOA (1.00) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL29358061 | 0.94 | MAOA (1.00) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL2354794 | 0.94 | MAOA (1.00) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL11399893 | 0.92 | MAOA (0.95) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL31110616 | 0.92 | MAOA (0.95) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL5376736 | 0.92 | MAOA (0.95) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL29060570 | 0.92 | MAOA (0.95) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL18556112 | 0.92 | MAOA (0.95) | MAOAKDM4EALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL4560050 | 0.92 | MAOA (0.95) | MAOAKDM4EALDH1A1CYP3A4GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509528-B1 | 1,3-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2008-09-24 | — | — | EP | disclosed |
| US-7232815-B2 | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | GLAXOSMITHKLINE (HR) | 2007-06-19 | — | — | US | disclosed |
| US-7166583-B2 | 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2007-01-23 | — | — | US | disclosed |
| EP-1492797-B1 | 1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF | PLIVA ISTRAZIVACKI INST D O O (HR) | 2006-03-15 | — | — | EP | disclosed |
| US-20050227963-A1 | 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2005-10-13 | — | — | US | disclosed |
| US-20050148576-A1 | 1-Oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
| US-20050130956-A1 | 1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-06-16 | — | — | US | disclosed |
| EP-0146360-A2 | Optically anisotropic melt forming copolyesters | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-06-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148576-A1 | 1-Oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | TNF, IL1A, IL1B | MAOA 1373/4885KDM4E 1436/4885ALDH1A1 42/4885 |
| US-20050130956-A1 | 1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof | TNF, IL1A, IL1B | MAOA 1231/4885KDM4E 1411/4885ALDH1A1 34/4885 |
| US-20050227963-A1 | 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | IL1A, TNF, IL1B | MAOA 2143/4885KDM4E 2573/4885ALDH1A1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.