SCHEMBL4696374

SCHEMBL4696374

Cc1ccc(NCCCN2CC3CN(C(=O)c4ccc(Br)cc4C)CC3C2)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.40
MAPT P10636 3/20 0.40
GAA P10253 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HTT P42858 2/20 0.40
LMNA P02545 1/20 0.40
RAB9A P51151 1/20 0.38
AGTR1 P30556 1/20 0.38
KDM4E B2RXH2 1/20 0.37
UBE2M P61081 2/20 0.37
DCUN1D1 Q96GG9 2/20 0.37
GPR6 P46095 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
AVPR2 P30518 2/20 0.36
HCRTR1 O43613 2/20 0.36
HCRTR2 O43614 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
MCHR1 Q99705 1/20 0.36
KCNK3 O14649 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4692994 0.94 AVPR2 (0.42) ALDH1A1MAPTGAASMN1; SMN2HTT
SCHEMBL4694297 0.93 KCNK3 (0.40) ALDH1A1MAPTGAASMN1; SMN2HTT
SCHEMBL4696360 0.92 ALDH1A1 (0.38) ALDH1A1MAPTGAASMN1; SMN2HTT
SCHEMBL4690742 0.91 HCRTR1 (0.46) ALDH1A1MAPTGAASMN1; SMN2HTT
SCHEMBL4690670 0.91 UBE2M (0.44) ALDH1A1MAPTGAASMN1; SMN2HTT
SCHEMBL4690931 0.88 MAPT (0.51) ALDH1A1MAPTSMN1; SMN2HTTLMNA
SCHEMBL4692889 0.88 MAPT (0.45) ALDH1A1MAPTGAASMN1; SMN2HTT
SCHEMBL4693961 0.87 HCRTR1 (0.46) ALDH1A1MAPTGAASMN1; SMN2HTT
SCHEMBL4690682 0.87 P2RX7 (0.44) ALDH1A1MAPTGAASMN1; SMN2HTT
SCHEMBL4692350 0.86 HCRTR1 (0.40) ALDH1A1MAPTGAASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed