Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028464 | 0.82 | STS (0.49) | HTTFKBP1AALDH1A1HSD17B10 | |
| SCHEMBL8843247 | 0.81 | HTT (0.44) | HTTFKBP1AHRH3ALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL8843229 | 0.81 | HTT (0.47) | HTTFKBP1AHRH3NPC1RAB9A | |
| SCHEMBL2552964 | 0.80 | EPHX1 (0.55) | FKBP1AEPHX1ALDH1A1DPP4GAA | |
| SCHEMBL22469702 | 0.80 | HTT (0.54) | HTTFKBP1AHRH3NPC1RAB9A | |
| SCHEMBL4443457 | 0.79 | EPHX1 (0.53) | FKBP1AEPHX1ALDH1A1DPP4GAA | |
| SCHEMBL31207275 | 0.79 | HRH3 (0.54) | HRH3HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL3745591 | 0.76 | RAB9A (0.49) | HPGDNPC1RAB9AEPHX1ALDH1A1 | |
| SCHEMBL8781552 | 0.76 | HTT (0.49) | HTTNPC1RAB9ANPSR1GAA | |
| SCHEMBL3352196 | 0.75 | ALDH1A1 (0.46) | HTTFKBP1AHRH3HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |