Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | PREP | P48147 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443457 | 0.99 | EPHX1 (0.53) | EPHX1ALDH1A1FKBP1AGAAMEN1 | |
| SCHEMBL7382767 | 0.85 | FKBP1A (0.53) | EPHX1ALDH1A1FKBP1AGAAMEN1 | |
| SCHEMBL31287332 | 0.84 | PREP (0.49) | EPHX1ALDH1A1FKBP1AGAADPP4 | |
| SCHEMBL31287268 | 0.82 | DPP4 (0.50) | EPHX1ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL6440981 | 0.81 | KLK7 (0.51) | EPHX1ALDH1A1FKBP1AGAAMEN1 | |
| SCHEMBL22469040 | 0.81 | FKBP1A (0.48) | EPHX1ALDH1A1FKBP1AGAAMEN1 | |
| SCHEMBL18398624 | 0.81 | PREP (0.50) | EPHX1ALDH1A1FKBP1AGAADPP4 | |
| SCHEMBL3732081 | 0.81 | ALDH1A1 (0.49) | EPHX1ALDH1A1GAADPP4KCNH2 | |
| SCHEMBL4696737 | 0.80 | HTT (0.51) | EPHX1ALDH1A1FKBP1AGAADPP4 | |
| SCHEMBL27978282 | 0.80 | FKBP1A (0.52) | FKBP1AKMT2ACTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556066-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124580-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-13 | — | — | WO | disclosed |