Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966924 | 0.84 | APEX1 (0.53) | RAPGEF4APEX1CA2CA4CA1 | |
| SCHEMBL156826 | 0.84 | RAPGEF4 (0.45) | RAPGEF4CA2CA1ALDH1A1MAPK1 | |
| SCHEMBL1109753 | 0.81 | RAPGEF4 (0.43) | RAPGEF4CA2CA1ALDH1A1MAPK1 | |
| SCHEMBL29844353 | 0.79 | AHR (0.34) | RAPGEF4APEX1ALDH1A1MAPK1TSHR | |
| SCHEMBL7111469 | 0.77 | TDP1 (0.41) | APEX1CA2CA4CA1CA6 | |
| SCHEMBL30101957 | 0.77 | RAPGEF4 (0.39) | RAPGEF4CA2CA1ALDH1A1MAPK1 | |
| SCHEMBL459156 | 0.77 | RAPGEF4 (0.39) | RAPGEF4ALDH1A1ALDH2ALDH3A1MAPT | |
| SCHEMBL29822788 | 0.73 | TDP1 (0.43) | APEX1CA2CA4CA1CA6 | |
| SCHEMBL180492 | 0.73 | TDP1 (0.43) | APEX1CA2CA4CA1CA6 | |
| SCHEMBL2226316 | 0.72 | APEX1 (0.35) | RAPGEF4APEX1CA2CA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790091-B | Substituted bis (trifluorovinyl) benzene compounds | 东曹精细化工株式会社 | 2021-06-15 | — | — | CN | disclosed |
| EP-3521266-B1 | SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND | TOSOH FINECHEM CORP (JP) | 2021-03-24 | — | — | EP | disclosed |
| US-10654779-B2 | Substituted bis(trifluorovinyl)benzene compound | TOSOH FINECHEM CORPORATION (JP) | 2020-05-19 | — | — | US | disclosed |
| US-20200017429-A1 | SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND | TOSOH FINECHEM CORPORATION (JP) | 2020-01-16 | — | — | US | disclosed |
| EP-3521266-A1 | SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND | Tosoh Finechem Corporation (JP) | 2019-08-07 | — | — | EP | disclosed |
| US-20100010058-A1 | Azoline Compounds for Combating Arthropod Pests | BASF SE (DE) | 2010-01-14 | — | — | US | disclosed |
| CN-100455570-C | Quinolinone/benzo oxazinone derivatives and uses thereof | HOFFMANN LA ROCHE (CH) | 2009-01-28 | — | — | CN | disclosed |
| US-20080312085-A1 | Pesticidal Compositions | BASF SE (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312085-A1 | Pesticidal Compositions | BASF SE (DE) | 2008-12-18 | — | — | US | disclosed |
| EP-1954673-A1 | HYDROXY-SUBSTITUTED DIPHENYLAZETIDINONES FOR THE TREATMENT OF HYPERLIPIDAEMIA | Sanofi-Aventis Deutschland GmbH (DE) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007147701-A1 | AZOLINE COMPOUNDS FOR COMBATING ARTHROPOD PESTS | BASF SE (DE) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007071585-A1 | PESTCIDAL COMPOSITIONS | BASF SE (DE) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007059871-A1 | HYDROXY-SUBSTITUTED DIPHENYLAZETIDINONES FOR THE TREATMENT OF HYPERLIPIDAEMIA | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-31 | — | — | WO | disclosed |
| CN-1759101-A | Quinolinone / benzoxazinone derivatives and uses thereof | HOFFMANN LA ROCHE (CH) | 2006-04-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654779-B2 | Substituted bis(trifluorovinyl)benzene compound | TCF7L2, AFF1, TYR | RAPGEF4 4295/4885APEX1 2900/4885CA2 2361/4885 |
| US-20200017429-A1 | SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND | TCF7L2, AFF1, TYR | RAPGEF4 4295/4885APEX1 2900/4885CA2 2361/4885 |
| US-20100010058-A1 | Azoline Compounds for Combating Arthropod Pests | NR0B1, NR4A1, NR4A3 | RAPGEF4 1810/4885APEX1 1668/4885CA2 1049/4885 |
| US-20080312085-A1 | Pesticidal Compositions | ANXA1, PRDX1, PRDX2 | RAPGEF4 2837/4885APEX1 104/4885CA2 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.