Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778579 | 0.84 | ACHE (0.40) | RAPGEF4ACHEALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL1551822 | 0.77 | RAPGEF4 (0.59) | RAPGEF4ACHEALDH1A1MAPTLMNA | |
| SCHEMBL28951 | 0.77 | RAPGEF4 (0.59) | RAPGEF4ACHEALDH1A1MAPTLMNA | |
| SCHEMBL5780229 | 0.77 | AHR (0.44) | ALDH1A1MAPTLMNAL3MBTL1CYP1A2 | |
| SCHEMBL4696777 | 0.77 | RAPGEF4 (0.39) | RAPGEF4ACHEALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL5180888 | 0.74 | RAPGEF4 (0.56) | RAPGEF4ACHEALDH1A1MAPTLMNA | |
| SCHEMBL28482658 | 0.74 | RAPGEF4 (0.56) | RAPGEF4ACHEALDH1A1MAPTLMNA | |
| SCHEMBL10412763 | 0.74 | RAPGEF4 (0.56) | RAPGEF4ACHEALDH1A1MAPTLMNA | |
| SCHEMBL1245480 | 0.73 | GAA (0.36) | ALDH1A1LMNAGAACYP1A2TSHR | |
| SCHEMBL12925873 | 0.72 | CES1 (0.36) | RAPGEF4ALDH1A1LMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12029736-B2 | Camptothecin derivatives and conjugates thereof | MEDIBOSTON LIMITED (HK) | 2024-07-09 | — | — | US | disclosed |
| US-20230242471-A1 | THYROMIMETICS | AUTOBAHN THERAPEUTICS, INC. | 2023-08-03 | — | — | US | disclosed |
| US-20230138502-A1 | MATERIALS FOR ORGANIC LIGHT EMITTING DEVICES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | US | disclosed |
| US-10968206-B2 | Cannabinergic nitrate esters and related analogs | NORTHEASTERN UNIVERSITY (US) | 2021-04-06 | — | — | US | disclosed |
| CN-107880028-B | Compound with aza-benzene as core and organic electroluminescent device | 中节能万润股份有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-107880027-B | Triazine-based compound and application thereof in organic electroluminescent device | 中节能万润股份有限公司 | 2021-03-02 | — | — | CN | disclosed |
| US-20190225596-A1 | Cannabinergic Nitrate Esters And Related Analogs | NORTHEASTERN UNIVERSITY | 2019-07-25 | — | — | US | disclosed |
| CN-109790091-A | Replace bis- (trifluoro vinyl) benzene compounds | 东曹精细化工株式会社 | 2019-05-21 | — | — | CN | disclosed |
| US-10221164-B2 | Cannabinergic nitrate esters and related analogs | NORTHEASTERN UNIVERSITY (US) | 2019-03-05 | — | — | US | disclosed |
| CN-107880027-A | It is a kind of using triazine as the compound of core and its application on organic electroluminescence device | 江苏三月光电科技有限公司 | 2018-04-06 | — | — | CN | disclosed |
| CN-1764647-A | Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2006-04-26 | — | — | CN | disclosed |
| EP-1611104-A1 | TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004085403-A1 | TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-10-07 | — | — | WO | disclosed |
| US-5356889-A | Carbapenicillins | MERCK & CO., INC. (US) | 1994-10-18 | — | — | US | disclosed |
| US-5144028-A | Antibiotics | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0472306-A1 | 2-(9-fluorenonyl)-carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1992-02-26 | — | — | EP | disclosed |
| EP-0469844-A1 | 2-(9-fluorenonyl)-carbapenem | MERCK & CO. INC. (US) | 1992-02-05 | — | — | EP | disclosed |
| US-5034384-A | Bactericides, antibiotics for resistant bacteria | MERCK & CO., INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-5025007-A | 2-(9-fluorenonyl)-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |
| US-4034007-A | Process for the production of halogenated aromatic carboxylic acids | TENNECO CHEMICALS, INC. (US) | 1977-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230138502-A1 | MATERIALS FOR ORGANIC LIGHT EMITTING DEVICES | DDT, ESD, ETFA | RAPGEF4 3124/4885ACHE 2533/4885ALDH1A1 389/4885 |
| US-12029736-B2 | Camptothecin derivatives and conjugates thereof | TOP2A, TOP1, XPA | RAPGEF4 178/4885ACHE 4421/4885ALDH1A1 1163/4885 |
| US-10968206-B2 | Cannabinergic nitrate esters and related analogs | CNR2, CNR1, CHRNB3 | RAPGEF4 1827/4885ACHE 36/4885ALDH1A1 1850/4885 |
| US-10221164-B2 | Cannabinergic nitrate esters and related analogs | CNR2, CNR1, CHRNB3 | RAPGEF4 1827/4885ACHE 36/4885ALDH1A1 1850/4885 |
| US-20190225596-A1 | Cannabinergic Nitrate Esters And Related Analogs | CNR2, CNR1, CHRNB3 | RAPGEF4 1827/4885ACHE 36/4885ALDH1A1 1850/4885 |
| US-20230242471-A1 | THYROMIMETICS | TPO, THOP1, THRB | RAPGEF4 1743/4885ACHE 50/4885ALDH1A1 1458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.