Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695275 | 0.89 | CHRM2 (0.35) | CHRM2MAPTALDH1A1GAAADRB2 | |
| SCHEMBL4692594 | 0.84 | CHRM2 (0.42) | CHRM2ALDH1A1ACHEMEN1KMT2A | |
| SCHEMBL5280124 | 0.82 | CHRM2 (0.46) | CHRM2ACHE | |
| SCHEMBL5273742 | 0.82 | NAMPT (0.35) | CHRM2MAPTF10DRD3NAMPT | |
| SCHEMBL6021912 | 0.80 | CHRM2 (0.56) | CHRM2ALDH1A1ACHERAB9A | |
| SCHEMBL4694973 | 0.80 | MCHR1 (0.40) | CHRM2HRH1DRD3HRH3ACHE | |
| SCHEMBL4692420 | 0.80 | MCHR1 (0.38) | CHRM2MAPTALDH1A1GAAACHE | |
| SCHEMBL4691377 | 0.79 | KMT2A (0.36) | MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL5807403 | 0.77 | SMYD2 (0.35) | CHRM2MAPTALDH1A1CHRM3MEN1 | |
| SCHEMBL5273313 | 0.76 | ATR (0.36) | MAPTALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | disclosed |