Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | DBH | P09172 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30526544 | 1.00 | MAPT (0.54) | MAPTSMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL12293826 | 0.85 | HTT (0.53) | MAPTSMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL31063263 | 0.82 | MAPT (0.49) | MAPTSMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL333582 | 0.82 | MAPT (0.56) | MAPTSMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL29463290 | 0.82 | MAPT (0.56) | MAPTSMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL580639 | 0.82 | MAPT (0.56) | MAPTSMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL2500053 | 0.82 | MAPT (0.56) | MAPTSMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL291363 | 0.81 | CA2 (0.68) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL4799519 | 0.81 | PTPN1 (0.41) | MAPTSMN1; SMN2L3MBTL1HTTCA2 | |
| SCHEMBL12765969 | 0.80 | MAPT (0.48) | MAPTSMN1; SMN2L3MBTL1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026766-A1 | Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors | BEIGENE, LTD. (KY) | 2025-01-23 | — | — | US | disclosed |
| US-20240277683-A1 | COMPOUNDS | CTXT PTY LTD (AU) | 2024-08-22 | — | — | US | disclosed |
| US-11911372-B2 | Compounds | CTXT PTY LTD (AU) | 2024-02-27 | — | — | US | disclosed |
| US-11911372-B2 | Compounds | CTXT PTY LTD (AU) | 2024-02-27 | — | — | US | disclosed |
| CN-117069724-A | Fused ring compounds, pharmaceutical compositions and uses | 上海赛默罗德生物科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| US-20210213004-A1 | Compounds | CTXT PTY LTD (AU) | 2021-07-15 | — | — | US | disclosed |
| EP-3813813-A1 | COMPOUNDS | CTXT Pty Limited (AU) | 2021-05-05 | — | — | EP | disclosed |
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| US-6617346-B1 | Inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity | HOFFMANN-LA ROCHE INC. | 2003-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240277683-A1 | COMPOUNDS | SLC10A1, ABCB11, REN | MAPT 1141/4885SMN1; SMN2 998/4885L3MBTL1 4767/4885 |
| US-20250026766-A1 | Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors | POLQ, POLK, POLI | MAPT 544/4885SMN1; SMN2 4018/4885L3MBTL1 2693/4885 |
| US-20210213004-A1 | Compounds | SLC10A1, ABCB11, REN | MAPT 1236/4885SMN1; SMN2 1164/4885L3MBTL1 4762/4885 |
| US-11911372-B2 | Compounds | SLC10A1, ABCB11, REN | MAPT 1236/4885SMN1; SMN2 1164/4885L3MBTL1 4762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.