Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204591 | 0.83 | CRHR1 (0.43) | CRHR1CNR1HSP90AA1HSP90AB1CDC7 | |
| SCHEMBL4696317 | 0.83 | CNR1 (0.44) | CRHR1CNR1GCGR | |
| SCHEMBL6204093 | 0.82 | CRHR1 (0.42) | CRHR1CNR1HSP90AA1HSP90AB1CDC7 | |
| SCHEMBL6201218 | 0.82 | CRHR1 (0.42) | CRHR1CNR1HSP90AA1HSP90AB1CDC7 | |
| SCHEMBL5517800 | 0.82 | CRHR1 (0.46) | CRHR1HSP90AA1HSP90AB1CDC7DBF4 | |
| SCHEMBL6203666 | 0.81 | CRHR1 (0.50) | CRHR1CNR1 | |
| SCHEMBL6204671 | 0.80 | CRHR1 (0.49) | CRHR1CNR1HSP90AA1HSP90AB1CDC7 | |
| SCHEMBL6201596 | 0.79 | CRHR1 (0.48) | CRHR1CNR1CDC7DBF4 | |
| SCHEMBL6204028 | 0.79 | CRHR1 (0.48) | CRHR1CNR1CDC7DBF4 | |
| SCHEMBL6203747 | 0.75 | CRHR1 (0.44) | CRHR1CNR1MAPTLIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871762-A2 | SUBTITUTED HETEROARYL CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006113704-A2 | SUBTITUTED HETEROARYL CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |