SCHEMBL4697065

SCHEMBL4697065

FC(F)(F)c1cccc(Oc2ccccc2Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.54
KMT2A Q03164 1/20 0.51
L3MBTL1 Q9Y468 4/20 0.49
STK39 Q9UEW8 1/20 0.48
TLR8 Q9NR97 1/20 0.47
TLR7 Q9NYK1 1/20 0.47
EGFR P00533 2/20 0.46
ERBB2 P04626 2/20 0.46
ERBB3 P21860 2/20 0.46
ERBB4 Q15303 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
MAPT P10636 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
TEAD1 P28347 1/20 0.44
ABCG2 Q9UNQ0 1/20 0.44
HTR2A P28223 1/20 0.43
SLC6A4 P31645 1/20 0.43
KCNH2 Q12809 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11121304 0.84 STK39 (0.50) KMT2AL3MBTL1STK39TLR8TLR7
SCHEMBL11430108 0.83 CYP3A4 (0.47) ARKMT2AL3MBTL1CYP2C9CYP2C19
SCHEMBL29638122 0.81 EGFR (0.53) L3MBTL1STK39EGFRERBB2ERBB3
SCHEMBL25917913 0.81 STK39 (0.50) KMT2AL3MBTL1STK39EGFRERBB2
SCHEMBL2747848 0.81 EGFR (0.53) L3MBTL1STK39EGFRERBB2ERBB3
SCHEMBL10538095 0.81 NPSR1 (0.57) KMT2AL3MBTL1STK39EGFRERBB2
SCHEMBL15832050 0.80 L3MBTL1 (0.60) L3MBTL1STK39EGFRERBB2ERBB3
SCHEMBL984918 0.80 STK39 (0.44) ARL3MBTL1STK39TLR8TLR7
SCHEMBL8941708 0.80 AR (0.54) ARL3MBTL1STK39NPSR1MAPT
SCHEMBL9546468 0.80 L3MBTL1 (0.49) KMT2AL3MBTL1NPSR1MAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1987037-A2 FUSED HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2008-11-05 EP claimed
WO-2007097470-A2 FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-30 WO claimed
EP-3350181-B1 HER3 LIGANDS AND USES THEREOF UNIV CALIFORNIA (US) 2023-11-01 EP disclosed
EP-1987037-A2 FUSED HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2008-11-05 EP disclosed
WO-2007097470-A2 FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-30 WO disclosed