Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | KYNU | Q16719 | 2/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788239 | 0.79 | HTR6 (0.51) | TP53MAPTALDH1A1 | |
| SCHEMBL23409831 | 0.79 | HTR6 (0.51) | TP53MAPTALDH1A1 | |
| SCHEMBL2645595 | 0.79 | PSIP1 (0.50) | PLCG1TP53MAPTALDH1A1GAA | |
| SCHEMBL18091016 | 0.78 | ALOX5AP (0.38) | ALOX5APFEN1KYNUPLCG1TP53 | |
| SCHEMBL23409832 | 0.78 | SIRT2 (0.40) | ALOX5APFEN1KYNUPLCG1GCGR | |
| SCHEMBL5340247 | 0.78 | PLCG1 (0.62) | ALOX5APFEN1PLCG1MAPT | |
| SCHEMBL5264466 | 0.78 | KYNU (0.60) | ALOX5APFEN1KYNUGAA | |
| SCHEMBL2705116 | 0.76 | ALOX5AP (0.50) | ALOX5APFEN1KYNUALDH1A1 | |
| SCHEMBL14009331 | 0.76 | ALOX5AP (0.39) | ALOX5APFEN1KYNUPTGES2 | |
| SCHEMBL2701996 | 0.76 | CA1 (0.52) | ALDH1A1SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987037-A2 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007097470-A2 | FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-30 | — | — | WO | disclosed |