SCHEMBL4697499

SCHEMBL4697499

Cc1ccc(NC(=O)C(O)CN2CC3CN(C(=O)c4cccc(C(F)(F)F)c4Cl)CC3C2)cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 19/20 0.49
NPY2R P49146 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4697502 0.88 P2RX7 (0.48) P2RX7
SCHEMBL4694022 0.86 P2RX7 (0.47) P2RX7NPY2R
SCHEMBL3283289 0.83 CCR5 (0.49)
SCHEMBL4694025 0.83 P2RX7 (0.48) P2RX7
SCHEMBL4694325 0.81 HCRTR1 (0.48)
SCHEMBL4693012 0.79 NPY2R (0.51) NPY2R
SCHEMBL4691177 0.78 NPY2R (0.43) P2RX7NPY2R
SCHEMBL4694034 0.78 MALT1 (0.46)
SCHEMBL4693868 0.76 CCR5 (0.48)
SCHEMBL4693018 0.76 NPY2R (0.47) NPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed