SCHEMBL469776

SCHEMBL469776

O=C(NCC(O)CBr)c1ccc(Cl)s1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.51
HPGD P15428 2/20 0.49
TSHR P16473 2/20 0.49
F10 P00742 3/20 0.44
LMNA P02545 2/20 0.44
GSK3B P49841 1/20 0.44
F2 P00734 1/20 0.43
DAO P14920 1/20 0.43
KDM4E B2RXH2 2/20 0.43
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12348258 1.00 MAPK1 (0.51) MAPK1HPGDTSHRF10LMNA
SCHEMBL498073 1.00 MAPK1 (0.51) MAPK1HPGDTSHRF10LMNA
SCHEMBL1136065 0.86 MAPK1 (0.52) MAPK1HPGDTSHRF10LMNA
SCHEMBL16416468 0.86 MAPK1 (0.52) MAPK1HPGDTSHRF10LMNA
SCHEMBL1136066 0.86 MAPK1 (0.52) MAPK1HPGDTSHRF10LMNA
SCHEMBL15221118 0.86 MAPK1 (0.52) MAPK1HPGDTSHRF10LMNA
SCHEMBL14830273 0.86 MAPK1 (0.52) MAPK1HPGDTSHRF10LMNA
SCHEMBL14838637 0.85 MAPK1 (0.51) MAPK1HPGDTSHRF10LMNA
SCHEMBL78371 0.85 MAPK1 (0.51) MAPK1HPGDTSHRF10LMNA
SCHEMBL28025617 0.85 MAPK1 (0.51) MAPK1HPGDTSHRF10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8106192-B2 Method for producing 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-01-31 US claimed
US-20100081807-A1 METHOD FOR PRODUCING 5-CLORO-N-(METHYL)-2-THIOPHENECARBOXAMIDE BAYER HEALTHCARE AG (DE) 2010-04-01 US claimed
US-20070149522-A1 Method for producing 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide BAYER HEALTHCARE AG (DE) 2007-06-28 US claimed
US-20170267669-A1 Process for the Preparation of Rivaroxaban CIPLA LIMITED (IN) 2017-09-21 US disclosed
EP-3186246-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN Cipla Limited (IN) 2017-07-05 EP disclosed
EP-2895176-B1 RIVAROXABAN INTERMEDIATE AND PREPARATION THEREOF WANBURY LTD (IN) 2016-10-19 EP disclosed
US-9394292-B2 Rivaroxaban intermediate and preparation thereof WANBURY LTD. (IN) 2016-07-19 US disclosed
WO-2016030669-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN CIPLA LIMITED (IN) 2016-03-03 WO disclosed
US-20150299160-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF RANBAXY LABORATORIES LIMITED (IN) 2015-10-22 US disclosed
US-20150299175-A1 RIVAROXABAN INTERMEDIATE AND PREPARATION THEREOF WANBURY LTD. (IN) 2015-10-22 US disclosed
US-20150133657-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN RANBAXY LABORATORIES LIMITED (IN) 2015-05-14 US disclosed
EP-2855465-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN Ranbaxy Laboratories Limited (IN) 2015-04-08 EP disclosed
EP-2838897-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF Ranbaxy Laboratories Limited (IN) 2015-02-25 EP disclosed
WO-2015011617-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN RANBAXY LABORATORIES LIMITED (IN) 2015-01-29 WO disclosed
WO-2013175431-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN RANBAXY LABORATORIES LIMITED (IN) 2013-11-28 WO disclosed
WO-2013156936-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF RANBAXY LABORATORIES LIMITED (IN) 2013-10-24 WO disclosed
WO-2013046211-A1 PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF SYMED LABS LIMITED (IN) 2013-04-04 WO disclosed
CN-102796092-A Oxazolidinone derivative, and preparation method and application thereof UNIV PEKING FOUNDER GROUP CO 2012-11-28 CN disclosed
WO-2012032533-A2 PROCESSES FOR THE PREPARATION OF 4-{4-[5(S)-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL]PHENYL} MORPHOLIN-3-ONE SYMED LABS LIMITED (IN) 2012-03-15 WO disclosed
US-20100184767-A1 SUBSTITUTED OXAZOLIDINONES AND USE THEREOF ROHRIG SUSANNE 2010-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100184767-A1 SUBSTITUTED OXAZOLIDINONES AND USE THEREOF XDH, OXA1L, PPOX MAPK1 3574/4885HPGD 221/4885TSHR 4286/4885
US-20150299160-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF VKORC1, CYP3A4, TFPI MAPK1 2718/4885HPGD 144/4885TSHR 2502/4885
US-20070149522-A1 Method for producing 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide NT5C, NOX5, MT-ND5 MAPK1 4432/4885HPGD 1313/4885TSHR 2837/4885
US-20100081807-A1 METHOD FOR PRODUCING 5-CLORO-N-(METHYL)-2-THIOPHENECARBOXAMIDE CBR3, NT5C, CBR1 MAPK1 4781/4885HPGD 885/4885TSHR 2510/4885
US-20170267669-A1 Process for the Preparation of Rivaroxaban F7, F5, F2 MAPK1 2591/4885HPGD 608/4885TSHR 3124/4885
US-20150133657-A1 PROCESS FOR THE PREPARATION OF RIVAROXABAN F2, VKORC1, F5 MAPK1 3846/4885HPGD 449/4885TSHR 2035/4885
US-20150299175-A1 RIVAROXABAN INTERMEDIATE AND PREPARATION THEREOF VKORC1L1, VKORC1, CYP3A5 MAPK1 2932/4885HPGD 713/4885TSHR 2032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.