Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702236 | 0.96 | P2RY12 (0.34) | F10P2RY12PDK1PDK2PDK3 | |
| SCHEMBL4698835 | 0.90 | ROCK2 (0.36) | ROCK2BDKRB2ALDH1A1GAAAGTR1 | |
| SCHEMBL4698936 | 0.88 | BDKRB2 (0.36) | ROCK2F10P2RY12PDK1PDK2 | |
| SCHEMBL4698850 | 0.86 | BDKRB2 (0.35) | ROCK2BDKRB2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL4699886 | 0.84 | ROCK2 (0.38) | ROCK2PDK1PDK2PDK3PDK4 | |
| SCHEMBL6386247 | 0.82 | ALDH1A1 (0.37) | ROCK2ALDH1A1GAAAGTR1HTT | |
| SCHEMBL4699908 | 0.80 | RAB9A (0.40) | ROCK2PDK1PDK2PDK3PDK4 | |
| SCHEMBL6386788 | 0.80 | BDKRB2 (0.39) | ROCK2BDKRB2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4698844 | 0.79 | ROCK2 (0.34) | ROCK2GPBAR1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4703627 | 0.78 | KMT2A (0.37) | ROCK2PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458684-B1 | THERAPEUTIC HETEROCYCLES AS BRADYKININ B2 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | claimed |