Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703680 | 0.93 | MAPT (0.45) | KCNMA1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16694958 | 0.91 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL16695029 | 0.91 | RAB9A (0.46) | MAPTALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL4702543 | 0.91 | MAPK1 (0.44) | KCNMA1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4699060 | 0.90 | MAPT (0.47) | KCNMA1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL4705056 | 0.89 | ALDH1A1 (0.41) | MAPTALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL1774056 | 0.85 | MAPT (0.60) | KCNMA1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4699964 | 0.85 | ALDH1A1 (0.45) | MAPTALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL4699968 | 0.83 | ALDH1A1 (0.45) | MAPTALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL16694831 | 0.82 | MAPT (0.52) | MAPTALDH1A1SMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966212-B1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2015-05-13 | — | — | EP | disclosed |
| EP-1966212-A1 | DIAZEPINONES | Merck Patent GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079826-A1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |