Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698990 | 0.93 | KCNMA1 (0.44) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL4705056 | 0.89 | ALDH1A1 (0.41) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL16695029 | 0.85 | RAB9A (0.46) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL4702543 | 0.85 | MAPK1 (0.44) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL16694958 | 0.85 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL1773787 | 0.85 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL4699060 | 0.85 | MAPT (0.47) | MAPTSMN1; SMN2MAPK1KMT2ALMNA | |
| SCHEMBL4699968 | 0.85 | ALDH1A1 (0.45) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL4699964 | 0.83 | ALDH1A1 (0.45) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL16694831 | 0.82 | MAPT (0.52) | MAPTALDH1A1SMN1; SMN2SYKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966212-B1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2015-05-13 | — | — | EP | disclosed |
| EP-1966212-A1 | DIAZEPINONES | Merck Patent GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079826-A1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |