Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695029 | 0.94 | RAB9A (0.46) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4698990 | 0.90 | KCNMA1 (0.44) | MAPTLMNAKCNMA1SMN1; SMN2KMT2A | |
| SCHEMBL16694958 | 0.89 | MAPT (0.41) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4702543 | 0.89 | MAPK1 (0.44) | MAPTLMNAKCNMA1SMN1; SMN2KMT2A | |
| SCHEMBL4705056 | 0.86 | ALDH1A1 (0.41) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1773244 | 0.86 | MAPT (0.57) | MAPTLMNAKCNMA1SMN1; SMN2KMT2A | |
| SCHEMBL4698966 | 0.85 | KMT2A (0.46) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4703680 | 0.85 | MAPT (0.45) | MAPTLMNAKCNMA1SMN1; SMN2KMT2A | |
| SCHEMBL14000435 | 0.80 | KCNMA1 (0.48) | MAPTLMNAKCNMA1SMN1; SMN2KMT2A | |
| SCHEMBL16694831 | 0.80 | MAPT (0.52) | MAPTLMNASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966212-B1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2015-05-13 | — | — | EP | disclosed |
| EP-1966212-A1 | DIAZEPINONES | Merck Patent GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079826-A1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |