Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | HTR3A | P46098 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 11/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 11/20 | 0.42 |
| ▸ | ITGAL | P20701 | 11/20 | 0.42 |
| ▸ | RHEB | Q15382 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703446 | 0.88 | SIGMAR1 (0.48) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4704836 | 0.87 | DRD2 (0.42) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4699736 | 0.84 | HTR1A (0.57) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4702827 | 0.82 | DRD2 (0.51) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1513518 | 0.77 | DRD2 (0.58) | DRD2SIGMAR1 | |
| SCHEMBL4704154 | 0.76 | HTR1A (0.54) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4702868 | 0.76 | SIGMAR1 (0.51) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4703115 | 0.76 | SIGMAR1 (0.48) | HTR1AHTR3ADRD2SIGMAR1 | |
| SCHEMBL4704045 | 0.76 | SIGMAR1 (0.48) | HTR1AHTR3ADRD2SIGMAR1 | |
| SCHEMBL4698879 | 0.74 | SIGMAR1 (0.47) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613594-B1 | 4-(2-PHENYLSULFANYL-PHENYL)-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | LUNDBECK & CO AS H (DK) | 2008-03-26 | — | — | EP | disclosed |
| US-20070173522-A1 | 4-(2-Phenylsulfanyl-phenyl)-1,2,3,6- tetrahydropyridine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2007-07-26 | — | — | US | disclosed |
| EP-1613594-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087662-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173522-A1 | 4-(2-Phenylsulfanyl-phenyl)-1,2,3,6- tetrahydropyridine derivatives as serotonin reuptake inhibitors | TPH1, HTR2C, HTR1D | HTR1A 4/4885HTR3A 11/4885CYP1A2 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.