Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697643 | 0.87 | PARP1 (0.62) | PARP1PRMT5WDR77FAAH | |
| SCHEMBL4701664 | 0.83 | NPC1 (0.55) | PARP1PRMT5WDR77FAAH | |
| SCHEMBL4704345 | 0.81 | PARP1 (0.58) | PARP1 | |
| SCHEMBL4700129 | 0.81 | LMNA (0.51) | PARP1ENPP1 | |
| SCHEMBL4700393 | 0.81 | PARP1 (0.44) | PARP1PRMT5WDR77FAAH | |
| SCHEMBL4701170 | 0.81 | PARP1 (0.51) | PARP1PRMT5WDR77FAAH | |
| SCHEMBL4697402 | 0.80 | PARP1 (0.57) | PARP1 | |
| SCHEMBL4703001 | 0.80 | FAAH (0.51) | PARP1PRMT5WDR77FAAH | |
| SCHEMBL4701162 | 0.80 | FAAH (0.52) | PARP1PRMT5WDR77FAAHENPP1 | |
| SCHEMBL4698403 | 0.80 | FAAH (0.55) | PARP1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427708-B1 | AMINO-PHTHALAZINONE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER ITALIA SRL (IT) | 2008-09-10 | — | — | EP | claimed |