Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174123 | 0.83 | HNF4A (0.58) | HNF4ABCAT2TACR1KMT2AMEN1 | |
| SCHEMBL2832469 | 0.81 | BCAT2 (0.62) | HNF4ABCAT2TACR1KMT2AMEN1 | |
| SCHEMBL27654634 | 0.81 | HNF4A (0.46) | HNF4ABCAT2TACR1KMT2AMEN1 | |
| SCHEMBL28498922 | 0.78 | HNF4A (0.44) | HNF4ABCAT2TACR1KMT2AMEN1 | |
| SCHEMBL27652110 | 0.76 | KMT2A (0.37) | HNF4ATACR1KMT2AALDH1A1 | |
| SCHEMBL940482 | 0.72 | HSD17B10 (0.48) | HNF4ASMN1; SMN2ALDH1A1FABP4TSHR | |
| SCHEMBL28334899 | 0.71 | DDT (0.54) | HNF4APDK2 | |
| SCHEMBL5132773 | 0.71 | ALDH1A1 (0.56) | HNF4AALDH1A1TSHRPDK2L3MBTL1 | |
| SCHEMBL2524408 | 0.70 | PTPN1 (0.46) | HNF4ABCAT2ALDH1A1FABP4FABP3 | |
| SCHEMBL3424186 | 0.70 | PTGS1 (0.49) | KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618099-A4 | BIARYL SUBSTITUTED THIAZOLES, OXAZOLES AND IMIDAZOLES AS SODIUM CHANNEL BLOCKERS | MERCK & CO INC (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1618099-A2 | BIARYL SUBSTITUTED THIAZOLES, OXAZOLES AND IMIDAZOLES AS SODIUM CHANNEL BLOCKERS | Merck & Co., Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094395-A2 | BIARYL SUBSTITUTED THIAZOLES, OXAZOLES AND IMIDAZOLES AS SODIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2004-11-04 | — | — | WO | disclosed |