SCHEMBL4700846

SCHEMBL4700846

COC(=O)c1ccc(S(C)(=O)=O)c(C)c1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA9 Q16790 2/20 0.45
CA5A P35218 1/20 0.45
VCAM1 P19320 1/20 0.44
KDM4E B2RXH2 4/20 0.44
HSD17B10 Q99714 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CDK1 P06493 1/20 0.43
FFAR4 Q5NUL3 1/20 0.42
KMT2A Q03164 1/20 0.41
CA12 O43570 1/20 0.41
CA7 P43166 1/20 0.41
PDK2 Q15119 1/20 0.41
PDK4 Q16654 1/20 0.41
CA14 Q9ULX7 1/20 0.41
LMNA P02545 2/20 0.40
ALDH1A1 P00352 4/20 0.40
TSHR P16473 1/20 0.39
MAPT P10636 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1357981 0.86 CA1 (0.42) CA1CA2CA9CA5AVCAM1
SCHEMBL4268094 0.85 KDM4E (0.44) CA1CA2CA9CA5AVCAM1
SCHEMBL4787568 0.85 CA2 (0.45) CA1CA2CA9CA5AVCAM1
SCHEMBL5548265 0.85 CA1 (0.41) CA1CA2CA9CA5AVCAM1
SCHEMBL4703972 0.84 CDK1 (0.40) CA1CA2CA9CA5AVCAM1
SCHEMBL4703905 0.83 CA2 (0.41) CA1CA2CA9CA5AVCAM1
SCHEMBL3422644 0.82 CA12 (0.54) CA1CA2CA9KDM4EHSD17B10
SCHEMBL4700345 0.80 VCAM1 (0.38) CA1CA2CA9CA5AVCAM1
SCHEMBL30620545 0.80 VCAM1 (0.38) CA1CA2CA9CA5AVCAM1
SCHEMBL4700348 0.80 VCAM1 (0.38) CA1CA2CA9CA5AVCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116947716-A Preparation method of 2, 3-dimethyl-4-methylsulfonyl methyl benzoate 绍兴贝斯美化工股份有限公司 2023-10-27 CN claimed
CN-116947775-A Preparation method of 3- (4, 5-dihydro-3-isoxazolyl) -2-methyl-4-methylsulfonyl methyl benzoate 绍兴贝斯美化工股份有限公司 2023-10-27 CN claimed
CN-116947716-A Preparation method of 2, 3-dimethyl-4-methylsulfonyl methyl benzoate 绍兴贝斯美化工股份有限公司 2023-10-27 CN disclosed
CN-116947716-A Preparation method of 2, 3-dimethyl-4-methylsulfonyl methyl benzoate 绍兴贝斯美化工股份有限公司 2023-10-27 CN disclosed
CN-116947716-A Preparation method of 2, 3-dimethyl-4-methylsulfonyl methyl benzoate 绍兴贝斯美化工股份有限公司 2023-10-27 CN disclosed
CN-116947775-A Preparation method of 3- (4, 5-dihydro-3-isoxazolyl) -2-methyl-4-methylsulfonyl methyl benzoate 绍兴贝斯美化工股份有限公司 2023-10-27 CN disclosed
CN-113862703-B Preparation method of topramezone intermediate 江苏七洲绿色科技研究院有限公司 2023-06-20 CN disclosed
CN-110183392-B Preparation method of 3-substituted phenyl-4, 5-dihydroisoxazole derivative, application and intermediate thereof 河北医科大学 2023-03-28 CN disclosed
CN-112745270-B Novel compound and method for preparing topramezone intermediate by using same 河北医科大学 2023-02-24 CN disclosed
CN-113862703-A Preparation method of topramezone intermediate 江苏七洲绿色科技研究院有限公司 2021-12-31 CN disclosed
CN-112745270-A Novel compound and method for preparing topramezone intermediate by using same 河北医科大学 2021-05-04 CN disclosed
EP-1031573-B1 NOVEL BENZOYLPYRAZOLE COMPOUNDS, INTERMEDIATES, AND HERBICIDES NIPPON SODA CO (JP) 2008-03-26 EP disclosed
EP-0990649-B1 BENZOYLPYRAZOLE DERIVATIVES HAVING SPECIFIED SUBSTITUENTS AND HERBICIDES NIPPON SODA CO (JP) 2004-05-12 EP disclosed
EP-0900795-B1 BENZENE DERIVATIVES SUBSTITUTED BY HETEROCYCLES AND HERBICIDES NIPPON SODA CO (JP) 2004-04-21 EP disclosed
US-6147031-A Benzoylpyrazole compounds, intermediate preparing therefor and herbicides NIPPON SODA CO., LTD. (JP) 2000-11-14 US disclosed
EP-1031573-A1 NOVEL BENZOYLPYRAZOLE COMPOUNDS, INTERMEDIATES, AND HERBICIDES NIPPON SODA CO., LTD. (JP) 2000-08-30 EP disclosed
EP-0990649-A1 BENZOYLPYRAZOLE DERIVATIVES HAVING SPECIFIED SUBSTITUENTS AND HERBICIDES NIPPON SODA CO., LTD. (JP) 2000-04-05 EP disclosed
US-5939360-A HERBICIDES WITH HYDROXYPYRAZOLEISOOXAZOLE KETONES NIPPON SODA CO., LTD. (JP) 1999-08-17 US disclosed
CN-1216543-A Heterocyclic substituted benzene derivatives and herbicides NIPPON SODA CO (JP) 1999-05-12 CN disclosed
EP-0900795-A1 BENZENE DERIVATIVES SUBSTITUTED BY HETEROCYCLES AND HERBICIDES NIPPON SODA CO., LTD. (JP) 1999-03-10 EP disclosed