Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 11/20 | 0.68 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.58 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566112 | 0.89 | MIF (0.64) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL17274310 | 0.86 | NAAA (0.63) | MIFTAAR1CALM1 | |
| SCHEMBL332410 | 0.84 | MIF (0.79) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL1845479 | 0.81 | TAAR1 (0.50) | MIFTAAR1AOC3MAOBCALM1 | |
| SCHEMBL1981190 | 0.81 | MIF (0.49) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL354853 | 0.81 | MIF (1.00) | MIFTRPA1TAAR1IDO1 | |
| SCHEMBL20357334 | 0.81 | MIF (0.54) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL3364900 | 0.79 | MIF (0.66) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL8763660 | 0.78 | MIF (0.70) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL1973945 | 0.77 | ATM (0.54) | MIFTRPA1CYP2E1CYP2A6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112913849-A | Pesticide composition containing isothiocyanate compounds and application of pesticide composition in prevention and treatment of plant diseases | 兰州大学 | 2021-06-08 | — | — | CN | claimed |
| US-11787794-B2 | Aminothiazole compounds and methods using same | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-10-17 | — | — | US | disclosed |
| CN-112913849-A | Pesticide composition containing isothiocyanate compounds and application of pesticide composition in prevention and treatment of plant diseases | 兰州大学 | 2021-06-08 | — | — | CN | disclosed |
| CN-112913849-A | Pesticide composition containing isothiocyanate compounds and application of pesticide composition in prevention and treatment of plant diseases | 兰州大学 | 2021-06-08 | — | — | CN | disclosed |
| US-20200071314-A1 | Novel Aminothiazole Compounds and Methods Using Same | UNIV TEMPLE (US) | 2020-03-05 | — | — | US | disclosed |
| US-10513516-B2 | Aminothiazole compounds and methods using same | Temple University—Of the Commonwealth System of Higher Education (US) | 2019-12-24 | — | — | US | disclosed |
| US-20180215750-A1 | Novel Aminothiazole Compounds and Methods Using Same | Temple University--of the Commonwealth System of Higher Education | 2018-08-02 | — | — | US | disclosed |
| EP-3324962-A1 | NOVEL AMINOTHIAZOLE COMPOUNDS AND METHODS USING SAME | Temple University Of The Commonwealth System Of Higher Education (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017015484-A1 | NOVEL AMINOTHIAZOLE COMPOUNDS AND METHODS USING SAME | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-01-26 | — | — | WO | disclosed |
| EP-1330451-B1 | SUBSTITUTED BENZIMIDAZOL-2-ONES AS VASOPRESSIN RECEPTOR ANTAGONISTS AND NEUROPEPTIDE Y MODULATORS | ORTHO MCNEIL PHARM INC (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1056732-B1 | 4-AMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | AGOURON PHARMA (US) | 2006-01-11 | — | — | EP | disclosed |
| CN-1159315-C | 4, 5-pyrrolooxindoles | - | 2004-07-28 | — | — | CN | disclosed |
| US-20030220326-A1 | Compounds, pharmaceutical compositions, and methods for inhibiting cyclin-dependent kinases | CHONG WESLEY K M (US) | 2003-11-27 | — | — | US | disclosed |
| US-6569878-B1 | Such as 4-amino-2-phenylamino-thiazol-5-yl)-(3-nitrophenyl)-methanone for treating cancer | AGOURON PHARMACEUTICALS INC. | 2003-05-27 | — | — | US | disclosed |
| EP-1215208-A2 | 4-Aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases | Agouron Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| CN-1330654-A | 4,5-pyrrolo-oxindoles | HOFFMANN LA ROCHE (DE) | 2002-01-09 | — | — | CN | disclosed |
| EP-1056732-A2 | 4-AMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999021845-A2 | 4-AMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 1999-05-06 | — | — | WO | disclosed |
| US-4127720-A | ANTIALLERGENS | BRISTOL-MYERS COMPANY (US) | 1978-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787794-B2 | Aminothiazole compounds and methods using same | BRCA1, ALDH7A1, MGMT | MIF 2346/4885TRPA1 1967/4885CYP2E1 440/4885 |
| US-20200071314-A1 | Novel Aminothiazole Compounds and Methods Using Same | BRCA1, SHMT2, MGMT | MIF 2192/4885TRPA1 1541/4885CYP2E1 2753/4885 |
| US-20030220326-A1 | Compounds, pharmaceutical compositions, and methods for inhibiting cyclin-dependent kinases | CDK2, CDK4, CDK1 | MIF 3286/4885TRPA1 4812/4885CYP2E1 784/4885 |
| US-10513516-B2 | Aminothiazole compounds and methods using same | BRCA1, ALDH7A1, AADAT | MIF 2245/4885TRPA1 1181/4885CYP2E1 548/4885 |
| US-20180215750-A1 | Novel Aminothiazole Compounds and Methods Using Same | BRCA1, SHMT2, MGMT | MIF 2192/4885TRPA1 1541/4885CYP2E1 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.