Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702271 | 0.84 | CRHR1 (0.39) | CRHR1POLBMEN1KMT2A | |
| SCHEMBL4757562 | 0.83 | SMN1; SMN2 (0.39) | CYP1A2CYP2D6ALDH1A1LMNACRHR1 | |
| SCHEMBL4698855 | 0.81 | CRHR1 (0.44) | CYP1A2ALDH1A1LMNACRHR1HSD17B10 | |
| Hydrochloric Acid SCHEMBL4697950 | 0.80 | CRHR1 (0.44) | CYP1A2ALDH1A1LMNACRHR1HSD17B10 | |
| SCHEMBL4702341 | 0.80 | CRHR1 (0.40) | LMNACRHR1HRH4 | |
| SCHEMBL4700164 | 0.80 | SCN8A (0.44) | CRHR1 | |
| SCHEMBL4700554 | 0.80 | DRD4 (0.34) | CRHR1 | |
| SCHEMBL4702626 | 0.79 | HEXA (0.43) | POLBKDM4E | |
| SCHEMBL4701263 | 0.79 | CRHR1 (0.39) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4703706 | 0.78 | MEN1 (0.40) | LMNACRHR1POLBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |