Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.44 |
| ▸ | DRD2 | P14416 | 10/20 | 0.42 |
| ▸ | HTR1A | P08908 | 9/20 | 0.42 |
| ▸ | HTR7 | P34969 | 7/20 | 0.42 |
| ▸ | HTR6 | P50406 | 7/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4700363 | 0.94 | OPRM1 (0.42) | OPRM1OPRL1SLC6A4DRD2HTR1A | |
| Hydrochloric Acid SCHEMBL4703735 | 0.91 | OPRM1 (0.46) | OPRM1SLC6A4DRD2HTR1AHTR7 | |
| SCHEMBL4697998 | 0.91 | OPRM1 (0.46) | OPRM1SLC6A4DRD2HTR1AHTR7 | |
| SCHEMBL4702267 | 0.91 | OPRL1 (0.43) | OPRM1OPRL1SLC6A4DRD2HTR1A | |
| SCHEMBL4697762 | 0.91 | HTR1A (0.49) | SLC6A4DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL2778302 | 0.88 | OPRM1 (0.49) | OPRM1OPRL1SLC6A4DRD2HTR1A | |
| Citric Acid SCHEMBL4697719 | 0.85 | DRD2 (0.43) | SLC6A4DRD2HTR1AHTR2ADRD3 | |
| Citric Acid SCHEMBL4702258 | 0.85 | OPRL1 (0.38) | OPRM1OPRL1SLC6A4DRD2HTR1A | |
| SCHEMBL4700535 | 0.83 | HSD11B1 (0.51) | OPRM1OPRL1HTR1AHTR7 | |
| Citric Acid SCHEMBL2780302 | 0.82 | OPRM1 (0.43) | OPRM1OPRL1SLC6A4DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560823-B1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| EP-1560823-B1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1560823-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004043949-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |