Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 5/20 | 0.49 |
| ▸ | PYGM | P11217 | 5/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 13/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046058 | 0.88 | PYGL (0.55) | PYGLPYGMRIPK1 | |
| SCHEMBL4758773 | 0.84 | PYGL (0.52) | PYGLPYGMRIPK1CCNA2CDK2 | |
| SCHEMBL4704248 | 0.83 | PYGL (0.48) | PYGLPYGMRIPK1CCNA2CDK2 | |
| SCHEMBL6047127 | 0.83 | PYGL (0.53) | PYGLPYGMRIPK1BDKRB1 | |
| SCHEMBL6045987 | 0.78 | PYGL (0.58) | PYGLPYGMRIPK1CCNA2CDK2 | |
| SCHEMBL4790164 | 0.77 | BDKRB1 (0.39) | PYGLPYGMCCNA2CDK2CCNA1 | |
| SCHEMBL4705743 | 0.76 | CCKBR (0.67) | BDKRB1 | |
| SCHEMBL4704027 | 0.76 | CCKBR (0.67) | BDKRB1 | |
| SCHEMBL4704031 | 0.76 | CCKBR (0.67) | BDKRB1 | |
| SCHEMBL4703604 | 0.75 | BDKRB1 (0.39) | CCNA2CDK2CCNA1BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |