Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 11/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | PYGM | P11217 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14084971 | 0.88 | BDKRB1 (0.42) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4790213 | 0.85 | BDKRB1 (0.41) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4706230 | 0.83 | CDK2 (0.48) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4790284 | 0.83 | ITGB1 (0.49) | BDKRB1CCNA2CDK2CCNA1EPHX2 | |
| SCHEMBL4790676 | 0.82 | CDK2 (0.42) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4789701 | 0.82 | BDKRB1 (0.46) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4705774 | 0.82 | BDKRB1 (0.50) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4704248 | 0.81 | PYGL (0.48) | BDKRB1CCNA2CDK2CCNA1PYGL | |
| SCHEMBL4700796 | 0.79 | BDKRB1 (0.42) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4700783 | 0.78 | BDKRB1 (0.53) | BDKRB1KMT2AMAPTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |