Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 15/20 | 0.47 |
| ▸ | CTSS | P25774 | 15/20 | 0.47 |
| ▸ | CTSB | P07858 | 14/20 | 0.47 |
| ▸ | CTSK | P43235 | 11/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208960 | 0.87 | CTSL (0.48) | CTSLCTSSCTSBCTSK | |
| SCHEMBL6909712 | 0.85 | CTSS (0.39) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4702155 | 0.83 | CTSL (0.69) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4702170 | 0.83 | CTSL (0.69) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4699683 | 0.81 | CTSL (0.51) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4698847 | 0.80 | CTSB (0.55) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4701389 | 0.80 | CTSL (0.52) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4699025 | 0.79 | CTSL (0.48) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4698685 | 0.78 | CTSL (0.47) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4701660 | 0.78 | CTSS (0.41) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |
| US-7012075-B2 | Cathepsin cysteine protease inhibitors | MERCK & CO., INC. (US) | 2006-03-14 | — | — | US | disclosed |