Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 15/20 | 0.48 |
| ▸ | CTSS | P25774 | 14/20 | 0.48 |
| ▸ | CTSB | P07858 | 13/20 | 0.48 |
| ▸ | CTSK | P43235 | 10/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701917 | 0.87 | CTSL (0.47) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4699307 | 0.78 | CTSL (0.60) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4701389 | 0.78 | CTSL (0.52) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4702155 | 0.76 | CTSL (0.69) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4702170 | 0.76 | CTSL (0.69) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4698847 | 0.76 | CTSB (0.55) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4699683 | 0.74 | CTSL (0.51) | CTSLCTSSCTSBCTSK | |
| SCHEMBL6909712 | 0.74 | CTSS (0.39) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4701283 | 0.73 | CTSL (0.54) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4704047 | 0.73 | CTSL (0.54) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | disclosed |