Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702629 | 0.86 | CRHR1 (0.35) | CRHR1ALDH1A1MAPT | |
| SCHEMBL4701265 | 0.84 | CRHR1 (0.34) | CRHR1ALDH1A1MAPT | |
| SCHEMBL4698858 | 0.83 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL4702334 | 0.82 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL4703707 | 0.79 | CRHR1 (0.33) | CRHR1ALDH1A1 | |
| SCHEMBL4702277 | 0.76 | CRHR1 (0.43) | CRHR1ALDH1A1ADORA3ADORA1MAPT | |
| SCHEMBL3364667 | 0.75 | CRHR1 (0.40) | CRHR1MAPT | |
| SCHEMBL4702940 | 0.72 | CRHR1 (0.43) | CRHR1ALDH1A1MAPT | |
| SCHEMBL5776284 | 0.71 | ALDH1A1 (0.34) | CRHR1ALDH1A1MAPT | |
| SCHEMBL4700544 | 0.71 | CRHR1 (0.40) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |