Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702273 | 0.84 | CRHR1 (0.40) | CRHR1ALDH1A1MAPT | |
| SCHEMBL4697907 | 0.80 | MAPT (0.31) | KDM4EALDH1A1PKMHPGDTSHR | |
| SCHEMBL4698858 | 0.80 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL4702334 | 0.79 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL4702629 | 0.79 | CRHR1 (0.35) | CRHR1KDM4EALDH1A1MAPT | |
| SCHEMBL4701268 | 0.78 | CRHR1 (0.37) | CRHR1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL27615415 | 0.74 | — | — | |
| SCHEMBL3364667 | 0.72 | CRHR1 (0.40) | CRHR1KDM4EHSD17B10MAPT | |
| SCHEMBL4701262 | 0.71 | CRHR1 (0.49) | CRHR1TSHRMAPT | |
| SCHEMBL4701270 | 0.70 | CHRM2 (0.39) | CRHR1KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |