Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700167 | 0.89 | CRHR1 (0.36) | CRHR1KLKB1 | |
| SCHEMBL4702631 | 0.86 | POLB (0.36) | CRHR1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4701268 | 0.84 | CRHR1 (0.37) | CRHR1HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL4702339 | 0.83 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL4698860 | 0.83 | CRHR1 (0.44) | CRHR1ALDH1A1KDM4ELMNA | |
| SCHEMBL4702273 | 0.76 | CRHR1 (0.40) | CRHR1ADORA3ADORA1ALDH1A1MAPT | |
| SCHEMBL3364667 | 0.74 | CRHR1 (0.40) | CRHR1KDM4EMAPT | |
| SCHEMBL4702271 | 0.73 | CRHR1 (0.39) | CRHR1MEN1KMT2APOLB | |
| SCHEMBL4702269 | 0.72 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL4757564 | 0.71 | CRHR1 (0.36) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |