Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 10/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 6/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088665 | 0.87 | ADRA2A (0.38) | TRPM5TRPM4ADRA2AADRA2BADRA2C | |
| SCHEMBL4702666 | 0.83 | ADRA2A (0.37) | TRPM5TRPM4ADRA2AADRA2BADRA2C | |
| SCHEMBL5092292 | 0.81 | FFAR1 (0.43) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL17361494 | 0.79 | PNMT (0.41) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL17193850 | 0.79 | TRPM5 (0.41) | TRPM5ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9682302 | 0.79 | ADRA2A (0.40) | TRPM5TRPM4ADRA2AADRA2BADRA2C | |
| SCHEMBL18427870 | 0.79 | TRPM5 (0.41) | TRPM5ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL17193852 | 0.79 | ADRA2A (0.40) | TRPM5TRPM4ADRA2AADRA2BADRA2C | |
| SCHEMBL4706203 | 0.78 | ADRA2A (0.33) | TRPM5TRPM4ADRA2AADRA2BADRA2C | |
| SCHEMBL5097822 | 0.77 | MAP3K14 (0.42) | TRPM5TRPM4ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567489-B1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |
| US-20060166985-A1 | Pyrrolydin-2-one derivatives as inhibitors of thrombin and factor xa | GLAXO GROUP LIMITED (GB) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166985-A1 | Pyrrolydin-2-one derivatives as inhibitors of thrombin and factor xa | TFPI, TFPI2, SERPINC1 | TRPM5 3212/4885TRPM4 3972/4885ADRA2A 3888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.