Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15153143 | 0.90 | CHRM1 (0.46) | CHRM1TSHRKDM4ESMN1; SMN2LMNA | |
| SCHEMBL15153161 | 0.90 | CHRM1 (0.46) | CHRM1TSHRKDM4ESMN1; SMN2LMNA | |
| SCHEMBL4704760 | 0.87 | CHRM1 (0.48) | CHRM1TSHRMMP8POLBLMNA | |
| SCHEMBL4705390 | 0.86 | TSHR (0.46) | TSHRMMP8SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1312285 | 0.80 | MMP8 (0.50) | CHRM1TSHRMMP8KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL1311367 | 0.79 | MMP8 (0.49) | CHRM1TSHRMMP8KDM4EHSD17B10 | |
| SCHEMBL7708347 | 0.79 | KLKB1 (0.41) | — | |
| SCHEMBL4702059 | 0.78 | OPRD1 (0.41) | TSHRALDH1A1HTT | |
| SCHEMBL3738889 | 0.78 | CTSD (0.40) | TSHRPOLBSMN1; SMN2ALDH1A1TACR1 | |
| SCHEMBL3450371 | 0.77 | F10 (0.42) | CHRM1TSHRKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567489-B1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |