Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663543 | 0.88 | ALDH1A1 (0.48) | MEN1KMT2ARAB9AALDH1A1HTT | |
| SCHEMBL12481908 | 0.88 | TDP1 (0.43) | MEN1KMT2ARAB9AALDH1A1HTT | |
| SCHEMBL4700343 | 0.85 | CDK8 (0.43) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL8754543 | 0.82 | PYCR1 (0.50) | MEN1KMT2ARAB9AALDH1A1HTT | |
| SCHEMBL3080815 | 0.81 | HTR2C (0.40) | MEN1KMT2ARAB9AALDH1A1HTT | |
| SCHEMBL5260772 | 0.78 | MEN1 (0.46) | MEN1KMT2ARAB9AALDH1A1HTT | |
| SCHEMBL4686422 | 0.77 | CDK1 (0.34) | MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL1935709 | 0.75 | RAB9A (0.47) | MEN1KMT2ARAB9AALDH1A1HTT | |
| SCHEMBL12480587 | 0.75 | MAOB (0.45) | MEN1KMT2ARAB9AALDH1A1HTT | |
| SCHEMBL15051354 | 0.75 | EGFR (0.50) | MEN1KMT2ARAB9AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893578-A2 | NOVEL PIPERIDINE CARBOXYLIC ACID AMIDE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006129237-A2 | NOVEL PIPERIDINE CARBOXYLIC ACID AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-12-07 | — | — | WO | disclosed |