Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701677 | 0.86 | DHFR (0.39) | MCHR1MAPTPTGS2DHFRRXFP1 | |
| SCHEMBL5611764 | 0.85 | DHFR (0.43) | MCHR1MAPTALDH1A1PTGS2DHFR | |
| SCHEMBL4172941 | 0.85 | MCHR1 (0.42) | MCHR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4700676 | 0.84 | MCHR1 (0.37) | MCHR1MAPTPTGS2DHFRRXFP1 | |
| SCHEMBL4704274 | 0.83 | KDM4E (0.41) | MCHR1MAPTALDH1A1 | |
| SCHEMBL5612513 | 0.78 | GRM1 (0.46) | MCHR1MAPTALDH1A1PTGS2GRM1 | |
| SCHEMBL1688990 | 0.76 | GRM1 (0.47) | MCHR1MAPTALDH1A1PTGS2DHFR | |
| SCHEMBL5611544 | 0.74 | GRM1 (0.40) | MCHR1ALDH1A1PTGS2GRM1XDH | |
| SCHEMBL1689154 | 0.74 | MCHR1 (0.39) | MCHR1MAPTALDH1A1GRM1XDH | |
| SCHEMBL4699918 | 0.73 | MAPT (0.41) | MAPTALDH1A1PTGS2RXFP1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999132-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM, LLC (BM) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007120454-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM LLC (BM) | 2007-10-25 | — | — | WO | disclosed |