Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5611764 | 0.88 | DHFR (0.43) | DHFRXDHMCHR1GRM1PTGS2 | |
| SCHEMBL4704498 | 0.86 | MCHR1 (0.38) | DHFRXDHMCHR1GRM1PTGS2 | |
| SCHEMBL4704274 | 0.85 | KDM4E (0.41) | MCHR1MAPTMEN1KMT2A | |
| SCHEMBL4169089 | 0.85 | XDH (0.44) | DHFRXDHMCHR1GRM1RXFP1 | |
| SCHEMBL4700676 | 0.84 | MCHR1 (0.37) | DHFRXDHMCHR1GRM1PTGS2 | |
| SCHEMBL5612513 | 0.80 | GRM1 (0.46) | XDHMCHR1GRM1PTGS2MAPT | |
| SCHEMBL5611504 | 0.78 | AOC3 (0.44) | XDHMCHR1GRM1PTGS2MEN1 | |
| SCHEMBL4702957 | 0.77 | PTGS2 (0.39) | MCHR1GRM1PTGS2 | |
| SCHEMBL5611544 | 0.76 | GRM1 (0.40) | XDHMCHR1GRM1PTGS2MEN1 | |
| SCHEMBL1689154 | 0.76 | MCHR1 (0.39) | XDHMCHR1GRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999132-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM, LLC (BM) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007120454-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM LLC (BM) | 2007-10-25 | — | — | WO | disclosed |