Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 3/20 | 0.35 |
| ▸ | CASP7 | P55210 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5612513 | 0.90 | GRM1 (0.46) | GRM1MCHR1GABRA2GABRB2ALDH1A1 | |
| SCHEMBL5611764 | 0.87 | DHFR (0.43) | GRM1MCHR1GABRA2GABRB2ALDH1A1 | |
| SCHEMBL1688990 | 0.85 | GRM1 (0.47) | GRM1MCHR1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL1689444 | 0.83 | XDH (0.42) | GRM1MCHR1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL5611498 | 0.83 | MAPT (0.43) | MCHR1GABRA2GABRB2TSHRSMN1; SMN2 | |
| SCHEMBL5611504 | 0.83 | AOC3 (0.44) | GRM1MCHR1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL1689154 | 0.77 | MCHR1 (0.39) | GRM1MCHR1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL4701677 | 0.76 | DHFR (0.39) | GRM1MCHR1XDHPTGS2MEN1 | |
| SCHEMBL1689056 | 0.74 | MAPT (0.46) | GRM1MCHR1GABRA2GABRB2ALDH1A1 | |
| SCHEMBL4704498 | 0.74 | MCHR1 (0.38) | GRM1MCHR1ALDH1A1XDHPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | disclosed |