Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 5/20 | 0.37 |
| ▸ | CTSB | P07858 | 5/20 | 0.37 |
| ▸ | CTSS | P25774 | 5/20 | 0.37 |
| ▸ | CTSK | P43235 | 4/20 | 0.37 |
| ▸ | GHSR | Q92847 | 5/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704327 | 0.86 | CTSL (0.51) | CTSLCTSBCTSSCTSKTGFBR1 | |
| SCHEMBL4703890 | 0.84 | CTSS (0.40) | CTSLCTSBCTSSCTSKTGFBR1 | |
| SCHEMBL4701851 | 0.84 | CTSL (0.49) | CTSLCTSBCTSSCTSKTGFBR1 | |
| SCHEMBL4703605 | 0.78 | MEN1 (0.31) | — | |
| SCHEMBL4703744 | 0.77 | KDM4E (0.36) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4703503 | 0.77 | KDM4E (0.36) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4698962 | 0.75 | CTSL (0.37) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4700189 | 0.74 | CTSL (0.57) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4698882 | 0.74 | CTSL (0.42) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4698649 | 0.73 | CTSL (0.48) | CTSLCTSBCTSSCTSKTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |