Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703503 | 1.00 | KDM4E (0.36) | KDM4EUSP2ALDH1A1CTSKCTSS | |
| SCHEMBL6209286 | 0.82 | KDM4E (0.36) | KDM4EUSP2ALDH1A1CTSB | |
| SCHEMBL6209280 | 0.82 | KDM4E (0.36) | KDM4EUSP2ALDH1A1CTSB | |
| SCHEMBL4703605 | 0.82 | MEN1 (0.31) | — | |
| SCHEMBL4704327 | 0.78 | CTSL (0.51) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4703890 | 0.78 | CTSS (0.40) | KDM4EALDH1A1CTSKCTSSCTSL | |
| SCHEMBL4704891 | 0.77 | CTSL (0.37) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4701851 | 0.76 | CTSL (0.49) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6208514 | 0.75 | CTSL (0.37) | CTSSCTSLCTSB | |
| SCHEMBL4701689 | 0.72 | CTSB (0.47) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | disclosed |