Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261782 | 0.91 | PRKCZ (0.37) | PRKCZMKNK1NFE2L2CHRNB4CHRNA3 | |
| SCHEMBL5260910 | 0.87 | LTA4H (0.41) | NFE2L2SSTR2LTA4H | |
| SCHEMBL5262749 | 0.82 | SSTR2 (0.39) | NFE2L2SSTR2 | |
| SCHEMBL4705249 | 0.79 | SLC6A2 (0.39) | PRKCZMKNK1CHRNB4CHRNA3 | |
| SCHEMBL5260158 | 0.78 | CHRNB4 (0.48) | PRKCZCHRNB4CHRNA3LTA4H | |
| SCHEMBL7006966 | 0.78 | CHRNB4 (0.55) | PRKCZCHRNB4CHRNA3CHEK1SSTR2 | |
| SCHEMBL2172629 | 0.78 | CHRNB4 (0.51) | PRKCZCHRNB4CHRNA3CHEK1SSTR2 | |
| SCHEMBL5239690 | 0.77 | SSTR2 (0.41) | PRKCZMKNK1CHRNB4CHRNA3SSTR2 | |
| SCHEMBL12491869 | 0.77 | CHRNB4 (0.39) | PRKCZMKNK1CHRNB4CHRNA3CHEK1 | |
| SCHEMBL6645965 | 0.75 | CHRNB4 (0.44) | PRKCZMKNK1CHRNB4CHRNA3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | Amgen Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |