Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064975 | 0.89 | GPR119 (0.39) | GPR119KCNH2NR1H2NTRK1CYP3A4 | |
| SCHEMBL470479 | 0.87 | GPR119 (0.36) | GPR119KCNH2NR1H2NTRK1CYP3A4 | |
| SCHEMBL14730327 | 0.85 | GPR119 (0.35) | GPR119KCNH2NR1H2NR1H3CYP3A4 | |
| SCHEMBL149964 | 0.85 | GPR119 (0.38) | GPR119KCNH2NR1H2NTRK1CYP3A4 | |
| SCHEMBL149963 | 0.85 | GPR119 (0.38) | GPR119KCNH2NR1H2NTRK1CYP3A4 | |
| SCHEMBL149962 | 0.85 | GPR119 (0.38) | GPR119KCNH2NR1H2NTRK1CYP3A4 | |
| SCHEMBL14730205 | 0.85 | NTRK1 (0.34) | GPR119NR1H2NTRK1NR1H3ACKR3 | |
| SCHEMBL470743 | 0.84 | GPR119 (0.36) | GPR119KCNH2NR1H2NTRK1CYP3A4 | |
| SCHEMBL14730167 | 0.84 | GPR119 (0.37) | GPR119KCNH2NR1H2NR1H3CYP3A4 | |
| SCHEMBL470534 | 0.83 | GPR119 (0.41) | GPR119KCNH2NTRK1GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |